Fusion protein of HIV regulatory/accessory proteins

Protéine hybride des protéines régulateurs/accessoires de VIH

Fusionsprotein des regulatorische/akzessorische HIV Proteine

Abstract

The invention relates to fusion proteins comprising the amino acid sequence of at least four HIV proteins selected from Vif, Vpr, Vpu, Rev, Tat and Nef or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.

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Patent Citations (3)

    Publication numberPublication dateAssigneeTitle
    WO-0204493-A2January 17, 2002Chiron Corporation, University Of StellenboschPolynucleotides codant pour des polypeptides antigeniques du type c du vih, de tels polypeptides et leurs utilisations
    WO-0206303-A2January 24, 2002The Trustees Of The University Of PennsylvaniaDna vaccines encoding hiv accessory proteins
    WO-0236806-A2May 10, 2002The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human ServicesExpression vectors able to elicit improved immune response and methods of using same

NO-Patent Citations (1)

    Title
    AYYAVOO VELPANDI ET AL: "Immunogenicity of a novel DNA vaccine cassette expressing multiple human immunodeficiency virus (HIV-1) accessory genes.", AIDS (HAGERSTOWN), vol. 14, no. 1, 7 January 2000 (2000-01-07), pages 1 - 9, XP009014789, ISSN: 0269-9370

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