Abstract

本发明涉及可与M-CSF(优选为人类M-CSF)特异性结合并发挥抑制M-CSF的作用的抗体及其抗原结合部分。本发明还涉及人类抗M-CSF的抗体及其抗原结合部分。本发明还涉及抗体,其可为嵌合的、双特异性(bispecific)的、衍生的、单链抗体或融合蛋白的部分。本发明还涉及来自人类抗M-CSF抗体的分离的重链及轻链免疫球蛋白及编码此种免疫球蛋白的核酸分子。本发明还涉及制备人类抗M-CSF抗体的方法、包含这些抗体的组合物及使用该抗体与组合物用于诊断及治疗的方法。本发明还提供使用编码重链及/或轻链免疫球蛋白分子的核酸分子的基因疗法,其中该免疫球蛋白包括人类抗M-CSF抗体。本发明还涉及包含本发明核酸分子的转基因动物及转基因植物。
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodi es or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprisin g nucleic acid molecules of the present invention.

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